Abnormal endocrine pancreas function at birth in cystic fibrosis ferrets
نویسندگان
چکیده
منابع مشابه
Abnormal endocrine pancreas function at birth in cystic fibrosis ferrets.
Diabetes is a common comorbidity in cystic fibrosis (CF) that worsens prognosis. The lack of an animal model for CF-related diabetes (CFRD) has made it difficult to dissect how the onset of pancreatic pathology influences the emergence of CFRD. We evaluated the structure and function of the neonatal CF endocrine pancreas using a new CFTR-knockout ferret model. Although CF kits are born with onl...
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Cystic fibrosis is frequently complicated by endocrine disorders. Diabetes can be expected to affect most with CF and pancreatic insufficiency and varies widely in age of onset, but early identification and treatment improve morbidity and mortality. Short stature can be exacerbated by relative delay of puberty and by use of inhaled corticosteroids. Bone disease in CF causes fragility fractures ...
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Passini (1919) was apparently the first to describe a case of faulty digestion in an infant due to pancreatic disease, and it would appear from a brief survey of the literature that not many cases of cystic fibrosis of the pancreas have been reported in this country, whereas in the United States, since Andersen (1938) correlated the pancreatic changes with steatorrhoea and pneumonia to form the...
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BACKGROUND Electrochemical skin conductance measurement is an active electrophysiologic method in which incremental low direct voltage is applied on the skin. It generates a current due to reverse iontophoresis which previous studies suggested to be mostly related to chloride anion movements. As sweat chloride movements upon electric stimulation were likely to be impaired in cystic fibrosis (CF...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2012
ISSN: 0021-9738
DOI: 10.1172/jci60610